2026 NBA Picks & Odds: Experts and Model Back 76ers on Wednesday

A total of 12 NBA matchups are set for Wednesday, highlighted by LeBron James returning to the court as the Philadelphia 76ers visit the Indiana Pacers for a 7 p.m. ET tip-off. Midweek action around the league additionally features the Magic facing the Raptors, the Warriors taking on the Timberwolves, and the Thunder battling the Magic. For Wednesday’s top wagers, the SportsLine Projection Model favors James and the 76ers to beat the spread as 5.5-point road favorites against Indiana. The game’s total points line sits at 235.5, dropping two points since opening. In addition, SportsLine’s expert handicappers have finalized their premier NBA wagers, incorporating player proposition selections for Raptors vs. Magic along with Rockets vs. Bucks. Prior to finalizing your Wednesday NBA selections, review the finest recommendations provided by SportsLine’s skilled analysts and algorithm. Wager on NBA action using top Kalshi promotional code CBSSPORTS55 to receive a $55 reward:

Running 10,000 computer simulations per game, the SportsLine Projection Model has generated close to $19,000 in earnings for $100 bettors on its highest-ranked NBA picks since 2018, posting four-figure profits in five consecutive campaigns. Heading into the second week of the 2026-27 campaign, the system boasts an impressive 26-10 (72%) record on top spread choices across online sportsbooks extending back to the previous year. Bettors using these sports wagering platforms could have reaped substantial profits.

Top Wednesday NBA wagers (lines may fluctuate): 

  • 76ers (-5.5) against Pacers (-110)
  • Anthony Black, Magic, Exceed 13.5 overall points (-122)
  • Amen Thompson, Rockets, Exceed 25.5 combined points + rebounds (-125)

Tying these three selections together in a Wednesday NBA parlay offers odds of +525 (a $100 wager yields a $525 profit). Place NBA wagers using BetMGM promotion code CBSSPORTS to claim up to $1,500 in bonus credits:

76ers (-5.5) facing Pacers (-110)

Philadelphia has started the year 3-1 showcasing their revamped roster anchored by LeBron James, Jaylen Brown, Joel Embiid, and Tyrese Maxey. Although this marks only their second away contest this term, their previous road tilt resulted in a 106-100 victory against the title-holding Knicks. The 76ers boast the league’s sixth-ranked scoring defense, surrendering just 107 points per matchup. Conversely, Indiana stands at 2-2 overall and 0-1 on their home floor. Computer projections show Philadelphia covering the spread in 55% of scenarios. Unlock $200 in bonus wagers alongside 3 complimentary months of NBA League Pass following an initial $5 wager at DraftKings:

Anthony Black, Magic, Exceed 13.5 overall points (-122)

“Anthony Black is positioned for an expanded workload given the numerous injuries troubling Orlando,” noted SportsLine analyst Prop Bet Guy Doug. “With both Jalen Suggs and Paolo Banchero sidelined today, Black should take over primary point guard responsibilities. Over 23 games last year in Suggs’ absence, Black registered 17.8 points per contest, and he scored 18 points facing New York after Suggs left Sunday’s game.” Utilize Fanatics Sportsbook promotional code CBSFAN350 to obtain $350 in FanCash:

Amen Thompson, Rockets, Exceed 25.5 combined points + rebounds (-125)

“Houston could lean heavily into smaller rotations today because Alperen Sengun (back) and Steven Adams (calf) are unavailable,” observed SportsLine NBA authority Mike Barner. “Amen Thompson has excelled on the glass, grabbing 10 or more boards in three out of four outings. Alongside his glass-cleaning ability, he is scoring 17.0 points per game while connecting on 53.2% of his shots. Milwaukee operates at the NBA’s second-fastest tempo and ranks 19th in defensive efficiency, creating plenty of chances for Thompson to generate points and boards.” Activate bet365 promotion code CBSBET365 to collect $200 in bonus funds following your opening $10 wager, regardless of the outcome:

Looking for additional NBA selections?

You have examined several top NBA wagers for this evening. Now, access spread, total, and moneyline choices for all NBA games here, generated by the expert team and simulation engine that analyzes every matchup 10,000 times.