The Week 5 NFL schedule commences with a NFC West divisional contest, as the Los Angeles Rams are slated to play host to the San Francisco 49ers on ‘Thursday Night Football.’ The opening kickoff is scheduled for 8:15 p.m. Eastern Time at SoFi Stadium and the projected point total is 46.5 points. The game showcases a substantial NFL DFS player pool, including some of the most prominent players in the sport such as Christian McCaffrey, Matthew Stafford, Puka Nacua, and Kyren Williams. George Kittle (hamstring), Brandon Aiyuk (knee) and Brock Purdy (toe) are among the players who will be absent for the 49ers.
Identifying undervalued players at an affordable cost remains crucial for constructing a successful NFL DFS strategy in Showdown competitions — particularly with this matchup involving numerous high-profile players. Should you consider targeting prospective DFS values like Davante Adams, or Blake Corum to accompany the more well-known players for Thursday Night Football DFS lineups and NFL DFS stacks? Prior to finalizing any NFL DFS selections for Rams versus 49ers on Thursday Night Football on platforms such as DraftKings and FanDuel, ensure that you consult the NFL DFS lineup recommendations, strategy, and player stacks provided by SportsLine NFL daily Fantasy expert Jimmie Kaylor.
Kaylor serves as a NFL betting and DFS expert for SportsLine, and he started the 2022 NFL season by emerging victorious in DraftKings’ NFL Showdown Thursday Kickoff Millionaire competition. He outdid over 355,000 other participants in the contest and also boasts multiple five-figure tournament victories on his DFS record. Kaylor has been covering the NFL and college football for nearly a decade as a member of the Pro Football Writers of America, and his experience as a former college and NFL player provides him with a distinctive viewpoint when crafting his fantasy lineups and finalizing his betting selections.
Currently, Kaylor has directed his focus toward the Thursday Night Football contest between the 49ers and Rams and has just secured his top daily Fantasy football selections. You can only access his Thursday Night Football DFS selections and analysis at SportsLine.
Top NFL DFS picks, lineups, stacks for Rams vs. 49ers
One of Kaylor’s highly recommended DFS selections for Thursday Night Football is 49ers running back Christian McCaffrey. The former Stanford athlete had his 2024 season disrupted by an injury, which limited him to only four games. During that period, he rushed 50 times for 202 yards (4.0 yards per carry) and added 15 receptions for 146 yards, but did not reach the end zone.
In 2025, through the first three games, he has accumulated 52 carries for 176 rushing yards and caught 25 passes for 213 yards and one receiving touchdown, as he continues to be a dual-threat in the 49ers’ offense. Throughout his career, McCaffrey has compiled over 6,500 rushing yards and over 4,600 receiving yards, and he has earned multiple Pro Bowl selections and an NFL Offensive Player of the Year award in 2023. Learn about other players to consider right here.
A component of Kaylor’s optimal NFL DFS strategy also involves including Rams wide receiver Puka Nacua. The former fifth-round selection from BYU followed up his impressive rookie season with a commendable 2024 campaign, as he secured 79 passes for 990 yards (12.5 yards per catch) and recorded three touchdowns over 11 games. He has since cemented his position among the top wide receivers in the NFL today.
In 2025, through the first three games, he has been even more productive, hauling in 29 receptions for 333 yards and adding a rushing attempt for 52 yards. From a career perspective, Nacua has already earned recognition with Second-team All-Pro and Pro Bowl honors in 2023, and he holds rookie receiving records such as the most receiving yards in a rookie season. In Week 4, Nacua stood out with 13 catches for 170 yards and a touchdown in the Rams’ 27-20 victory over the Indianapolis Colts. You can discover the remainder of Kaylor’s NFL DFS selections here.
How to build NFL DFS lineups and stacks for 49ers vs. Rams
Kaylor is also focusing on another undervalued player who has the potential to produce significant statistics on Thursday Night Football. This particular selection could determine whether you win your tournaments and cash games or leave empty-handed. You can only find out who it is, and gain access to the rest of Kaylor’s NFL DFS selections, at SportsLine.
Therefore, who is Jimmie Kaylor featuring in his optimal NFL DFS lineups for 49ers versus Rams on Thursday Night Football, and which under-the-radar NFL DFS selections offer substantial value? Visit SportsLine now to view optimal NFL DFS selections, rankings, advice, and stacks, all from SportsLine’s established DFS expert who triumphed in a single-game millionaire maker tournament, and discover the answers.
