Crafting a solid NFL DFS game plan can manifest in numerous ways, yet a favored tactic involves targeting contests projected to yield considerable scores when pinpointing premier NFL DFS choices and assembling NFL DFS combinations. The most elevated projected total in the NFL betting lines for the Sunday primary slate stands at 49.5 in the Cowboys versus Panthers showdown. Other potentially high-scoring face-offs on Sunday encompass 49ers versus Buccaneers, Seahawks versus Jaguars, and Colts versus Cardinals. Consequently, anticipate luminaries such as Dak Prescott, Tetairoa McMillan, Christian McCaffrey and Jonathan Taylor to be pivotal figures in various NFL DFS formations.
However, competitors of such distinction will deplete your NFL DFS budget, compelling you to unearth more prospective NFL DFS hidden gems and NFL DFS economical options. Should performers like Daniel Jones or Baker Mayfield secure a place in your quarterback roster for Sunday’s main slate? Will underachieving talents like Ja’Marr Chase and Tee Higgins ultimately justify their valuations on NFL DFS platforms? Prior to finalizing any NFL DFS selections for Sunday or cementing NFL DFS squads on platforms such as DraftKings and FanDuel, ensure you consult SportsLine’s sophisticated NFL DFS lineup optimizer.
The DFS Optimizer leverages insights from the SportsLine Advanced-Data Projection Model and DFS Authority Mike McClure to discern leading DFS selections/plays for any slate on wagering applications like DraftKings and FanDuel. It replicates each game 10,000 instances to aid DFS participants in refining and constructing triumphant DraftKings and FanDuel lineups. Enhance, export, and confidently field lineups with injury reports, projected player floors and ceilings, and Vegas odds and selections, all consolidated within a singular victorious tool for sports gambling applications.
Presently, SportsLine’s NFL DFS Optimizer has directed its attention towards Sunday’s 2025 NFL Week 6 agenda and has just secured its foremost daily Fantasy football lineups. Its optimal lineups are exclusively accessible at SportsLine.
Leading NFL Week 6 DFS selections for Sunday
One of the optimizer’s prime DFS economical selections for Sunday is Cowboys quarterback Dak Prescott ($6,500 on DraftKings and $8,000 on FanDuel). The former fourth-round selection from Mississippi State had his 2024 season truncated by injury, yet he still managed to accumulate 1,978 passing yards with 11 touchdowns and eight interceptions across eight contests, culminating in an 86.0 passer rating. In 2025, he has rebounded with one of his most productive starts in recent memory.
Across five weeks, Prescott boasts 1,356 passing yards, 10 touchdowns, and merely three interceptions. The 32-year-old has reestablished his cadence as the vanguard of the Cowboys’ offensive unit, demonstrating refined decision-making and precision. His capacity to prolong plays and execute under duress has been a significant element in sustaining Dallas’s competitiveness in the early stages of the season. Discover additional selections here.
The optimizer’s NFL DFS blueprint also incorporates enlisting Rams running back Kyren Williams ($6,300 on DraftKings and $8,400 on FanDuel). The former fifth-round selection from Notre Dame emerged onto the 2024 season as the Rams’ primary ball carrier, conveying the ball 316 times for 1,299 yards and securing 14 rushing touchdowns, while concurrently amassing 34 receptions for 182 receiving yards. His volume and adaptability distinguished him as one of L.A.’s most dependable offensive resources.
In 2025, he’s commencing another robust start. Across five weeks, he has already registered 82 carries for 368 yards (4.5 yards per carry) with one rushing score, and contributed as a receiver with 16 catches for 118 yards and three receiving touchdowns. Despite apportioning some of the workload with Blake Corum, Williams persists as the focal point of the backfield and has even secured a three-year, $33 million contract extension from the Rams. You can examine the remaining optimizer’s NFL DFS picks here.
Guidance on structuring Sunday Week 6 NFL DFS lineups
The NFL DFS Optimizer is additionally pinpointing multiple undervalued participants who could detonate for substantial figures on Sunday. These participants could represent the critical element between triumphing in your tournaments and cash games or departing empty-handed. Their identities, alongside the optimizer’s remaining NFL DFS selections, are exclusively accessible at SportsLine.
Consequently, what constitutes the supreme NFL DFS lineup for Sunday, and which overlooked NFL DFS selections present substantial value? Access SportsLine now to peruse optimal NFL DFS selections, rankings, advice, and stacks, all originating from an NFL DFS optimizer that replicates each game 10,000 instances, and ascertain the answer.
