NFL Week 1 2025 Picks: Simulation’s Best Bets & 25-1 Parlay

The intensity ignites on Opening Day for the Cincinnati Bengals, who commence their 2025 NFL campaign with a road trip to Cleveland. Cincinnati was absent from the postseason picture the prior year, despite a stellar performance from their quarterback, Joe Burrow, who was in contention for the MVP award. The Bengals, who concluded 2024 with a five-game winning streak, are set to clash with a Cleveland Browns squad that has designated Joe Flacco as their starting quarterback for Week 1. The Bengals are tagged as 5.5-point favorites, but Burrow’s record against Cleveland stands at 3 wins and 5 losses. Will the Bengals be a reliable choice for your Week 1 NFL parlay selections?

Aaron Rodgers is slated to face his former associates when the Pittsburgh Steelers journey to encounter the New York Jets in the opening week. According to the recent Week 1 NFL projections, the Steelers are favored by 2.5 points on the road, with the over/under for the cumulative score fixed at 38.5, marking it as the solitary game with a total below 40. Which team presents a valuable addition to Week 1 NFL wagers, and which aspect of the NFL odds merits your attention? Prior to solidifying your Week 1 NFL picks or NFL parlays, ensure you consult the NFL forecasts and wagering insights provided by SportsLine’s proven computational model.

The model, executing 10,000 simulations for each NFL game, has amassed earnings exceeding $7,000 for individuals wagering $100 on highly-rated NFL selections since its inception. In 2024, the model boasted a 31-15 record on its premier selections. Those adhering to its NFL wagering recommendations across sportsbooks and various betting platforms could have realized substantial returns.

Presently, the model has meticulously examined the Week 1 NFL odds and identified five high-confidence NFL recommended wagers. An accurate parlay of these sports betting selections could yield a substantial payout nearing 25-1. The model’s Week 1 NFL picks are exclusively accessible on SportsLine, and new patrons can also explore the DraftKings promo code, granting $300 in instant bonus wagers along with over $200 off NFL Sunday Ticket:

Top Week 1 NFL picks

Following 10,000 simulations of each game, the model expresses strong confidence in the Washington Commanders (-6, 45.5) covering the spread against the New York Giants. Washington previously advanced to the NFC Championship Game. The Commanders had achieved a seven-game winning sequence leading up to that contest, fueled by the performance of Jayden Daniels, currently in his second season. Daniels demonstrated dominance in 2024, completing 69% of his passes for 3,568 yards, accompanied by 25 touchdowns and only nine interceptions. In a divisional round victory over the Detroit Lions with a score of 45-31, Daniels completed 22 of 31 passes for 299 yards and two touchdowns, without a single interception. 

After resolving his contract-related complications, star receiver Terry McLaurin has secured a new agreement, ensuring his presence in the lineup for the season opener. The Commanders emerged victorious in both encounters last season, and the model anticipates them covering the spread in over 60% of the simulations, designating it as an A-rated pick. Discover the other NFL parlay selections to consider here and wager on the Commanders to cover here:

How to make Week 1 NFL parlays

The model has also pinpointed four other NFL contests where it asserts a significant discrepancy in the line, notably endorsing an underdog that it anticipates will not only cover the spread but also secure an outright victory. The model’s Week 1 NFL optimal wagers and NFL parlay options are exclusively available on SportsLine.

What constitute the model’s foremost Week 1 NFL picks, and which NFL matchups warrant consideration for a potentially lucrative 25-1 payout? Navigate to SportsLine to scrutinize the Week 1 NFL recommended wagers from a model demonstrating a 31-15 track record on top-tier selections, and gain further insights.

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