Sinner, whose quest to defend his Australian Open title was halted by Djokovic during a captivating five-set semi-final in January, further improved his head-to-head record against Medvedev, emerging victorious in nine out of their last ten encounters.
The Italian player successfully avoided any break points from Medvedev, conceding only four points when serving with his first attempt.
He secured his initial championship of the year and his twenty-fifth overall without surrendering a single set.
Notwithstanding his defeat, Medvedev is set to rejoin the top 10 positions once the updated rankings are released on Monday.
The previous US Open winner nearly missed participating in the event, as he was stranded in Dubai due to the continuing unrest in the Middle Eastern region.
Upon reaching the USA, Medvedev demonstrated the reasons for his past eminence in men’s tennis, following an impressive semi-final win against the top-ranked player globally, Carlos Alcaraz.
Nonetheless, it was Sinner who managed to prevail in the crucial junctures on Sunday, greatly aided by his dominant serving.
Sinner secured 43 out of 47 points on his first serve, delivered 10 aces, and claimed 60% of points when using his second serve, thereby maintaining command throughout the contest.
Medvedev successfully defended against both of the sole break points in the final, and nearly compelled a third set after taking a 4-0 lead during the tie-break.
Nevertheless, Sinner then consecutively scored seven points, concluding the match and earning consecutive Masters 1,000 championships without losing any set.
In other news, the third-ranked player globally, Djokovic, has pulled out of the Miami Open scheduled for this week due to an injury.
The esteemed Serbian athlete has triumphed in the tournament on six occasions and ended as the runner-up to Jakub Mensik in the previous year.
Nonetheless, the champion with 24 Grand Slam victories stated that a right shoulder ailment prevented his participation in the hard-court competition, commencing on Monday.