Mariners vs. Blue Jays: ALCS Game 6 Prediction, Odds & Betting Picks

The Seattle Mariners are aiming to secure their place in their inaugural World Series appearance as they face off against the Toronto Blue Jays in Game 6 of their American League Championship Series on Sunday. Seattle gained a 3-2 advantage in their best-of-seven series last Friday with a 6-2 victory. The Mariners (90-72), who clinched the AL West title, hold a 3-1 record on the road this postseason. The Blue Jays (94-68), champions of the AL East, have a 2-2 record at their home stadium in the playoffs. Despite leaving Game 5 early due to being hit by a pitch, George Springer (knee) is slated to be in the starting lineup.

The initial pitch is scheduled for 8:03 p.m. ET at Rogers Centre in Toronto. Toronto has emerged victorious in five of their last eight encounters with Seattle. Toronto is marked as a -122 favorite on the money line (requiring a $122 wager to potentially win $100) according to the latest Mariners vs. Blue Jays odds from DraftKings Sportsbook, while Seattle is listed at +102. The anticipated total number of runs to be scored, also known as the over-under, is set at 7.5. Before finalizing any Mariners vs. Blue Jays selections, be sure to consult the MLB forecasts and wagering insights provided by SportsLine’s reputable computer model. 

The SportsLine Projection Model conducts 10,000 simulations for each MLB game. Entering the ALCS and NLCS rounds of the 2025 MLB playoffs, it boasts a profitable record of 35-29 on its top-rated MLB money-line choices this season. The model has demonstrated excellence in predicting home run props this season, yielding almost 30 units of profit. Individuals who have been following its MLB wagering picks at sportsbooks and on betting platforms could have realized substantial returns.

The model has now focused its attention on Mariners vs. Blue Jays, finalizing its picks and MLB forecasts. Visit SportsLine now to access the model’s selections. Here are various MLB odds and betting lines for Blue Jays vs. Mariners:

Mariners vs. Blue Jays money line

Seattle +102, Toronto -122

Mariners vs. Blue Jays over/under

7.5 runs

Mariners vs. Blue Jays run line 

Toronto -1.5 (+164)

Mariners vs. Blue Jays picks

See picks at SportsLine

Mariners vs. Blue Jays streaming 

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Factors Favoring a Blue Jays Victory

Toronto is projected to send rookie right-hander Trey Yesavage (1-0, 3.21 ERA) to the pitcher’s mound. Over three regular-season appearances, Yesavage has thrown 14 innings, conceding 13 hits and five earned runs, accompanied by seven walks and 16 strikeouts. He has a postseason record of 1-1. He delivered a strong performance in a 13-7 triumph over the New York Yankees on Oct. 5 in the ALDS but struggled in a 10-3 ALCS Game 2 defeat to the Mariners. In the victory against New York, he pitched 5.1 innings, allowing no hits and one walk, while recording 11 strikeouts.

Throughout both the regular season and postseason, first baseman Vladimir Guerrero has been a driving force for Toronto. The five-time All-Star exhibits a 1.495 OPS in this year’s playoffs, marked by five home runs and 11 RBI across nine games. He has also achieved considerable success against Seattle’s starting pitcher, Logan Gilbert, with a 6-for-17 (.353) record, including four extra-base hits. Discover which team to support at SportsLine.

Reasons the Mariners Could Win

While Seattle has not officially announced their starting pitcher, Logan Gilbert (6-6, 3.44 ERA), who started Game 2, is likely to take the mound. He received a no-decision in that game, pitching three innings and allowing five hits, three runs – two earned – with one walk and two strikeouts. First baseman Josh Naylor stands out among Seattle’s leading hitters. This season, he posted a .295 batting average with 20 home runs, 92 RBI, and 81 runs scored. He joined the team in a midseason trade with the Arizona Diamondbacks.

Center fielder Julio Rodriguez also significantly contributes to the offensive firepower. Across 160 regular-season games, he batted .267 with 31 doubles, four triples, 32 home runs, and 95 RBI, along with 30 stolen bases. His performance has cooled off in the series’ last two games after a strong showing in Toronto for Games 1 and 2. Despite a .235 batting average over five games, he has two home runs and five RBI. Find out which team to back at SportsLine. 

Guidance for Making Mariners vs. Blue Jays Selections

SportsLine’s model anticipates an Over result on the total, projecting a combined score of 9.4 runs. It suggests that one side of the money line presents significant value. Access SportsLine to view the model’s MLB picks. 

Therefore, who will prevail in Mariners vs. Blue Jays, and which side of the money line offers the greatest value? Visit SportsLine now to determine which side to favor, all based on the model’s exceptional MLB picks success rate, and gain insights.

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